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T2320 |
Indacaterol
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Adrenergic Receptor
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Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist. |
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T15108 |
DG-041
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Prostaglandin Receptor
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DG-041 is an antagonist of high-affinity EP3 receptor (IC50s: 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively). DG-041 inhibits PGE2 facilitation of platelet aggregation and has the blood-brain barrier per... |
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T1479 |
Isosorbide dinitrate
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Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate |
Others
,
NO Synthase
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Isosorbide dinitrate (Isordil) is a vasodilator used in the treatment of angina pectoris. |
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T1239 |
Indacaterol maleate
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QAB149 |
Adrenergic Receptor
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Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist. |
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T3461 |
Losartan Carboxylic Acid
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EXP-3174,E-3174 |
RAAS
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Losartan Carboxylic Acid (E-3174) a potent AT1 antagonist (Kis: 0.57 nM, rat; 0.67 nM, human), producing a depressor response and vasodilatation. Losartan Carboxylic Acid , a metabolite of losartan, is more potent than l... |
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T15418 |
GS-6201
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CVT-6883 |
Adenosine Receptor
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GS-6201 (CVT-6883) is a selective antagonist of adenosine A2B receptor. GS-6201 shows high affinity and selectivity for the human adenosine A2B receptors with a Ki of 22 nM. |
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T5329 |
Trandolapril
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Angiotensin-converting Enzyme (ACE)
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Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that is hydrolysed to the active diacid trandolaprilat. |
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T7714 |
Temocapil
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Tyrosinase
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Temocapril is an inhibitor of tyrosine kinase. |
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T3230 |
NLRP3-IN-2
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5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,NLRP3 Inflammasome Inhibitor I |
NOD-like Receptor (NLR)
,
NOD
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NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation of NLRP3 inflammatory vesicles in cardiomyocytes, limiting i... |
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T6698 |
Temocapril hydrochloride
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CS-622 HCl,Acecol,Temocapril HCl,CS-622 |
RAAS
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Temocapril hydrochloride (CS-622 HCl), the hydrochloride of Temocapril, is a long-acting ACE inhibitor used for the therapy of hypertension. |
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T83977 |
BIIB 722 Mesylate
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Sodium Channel
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BIIB 722 Mesylate is a selective sodium-hydrogen exchange inhibitor with cardioprotective properties and can be used to study myocardial ischemia and myocardial infarction. |
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T11239 |
Ethacizine hydrochloride
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NIK-244,Ethacizin,NIK-244 hydrochloride |
Sodium Channel
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Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity, and its effects are related to cardiac activity and can be used to study arrhythmias and myocardial infarction. |
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T21821L |
REV 5901A
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REV 5901 HCl,REV 5901A（101910-24-1 Free base） |
Leukotriene Receptor
,
Lipoxygenase
,
Antibiotic
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REV 5901A (REV 5901 HCl) is an orally active leukotriene receptor antagonist and 5-lipoxygenase inhibitor with antimicrobial activity that attenuates colon cancer growth in mice.REV 5901A has been used in studies of asth... |
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T68022L |
Sulotroban potassium
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BM 13177 potassium,Sulotroban potassium(72131-33-0 Free base) |
PPAR
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Sulotroban potassium is a small molecule thromboxane A2 receptor (TXA2R) antagonist that can be used to study myocardial infarction and thrombosis. |
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T67941 |
PDE5-IN-9
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PDE5-IN-9 inhibits Phosphodiesterase PDE1c and is used to treat hypertension, heart failure, myocardial infarction, kidney failure, asthma, bronchitis, and dementia. |
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T24115 |
GSK854
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GSK-854,GSK 854 |
Apoptosis
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GSK854 is a highly selective and potent inhibitor of troponin I interacting kinase (TNNI3K) that inhibits myocardial infarction-injured cellular pyroptosis and apoptosis in mice, which may limit oxidative stress, injury,... |
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T12078 |
ML334
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LH601A |
Nrf2
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TP2279L |
Obestatin (rat) acetate
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GHSR
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Obestatin (rat) acetate is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin (rat) acetate has anti-inflammatory, anti-myocardial infarction and antioxidant properties. Obestatin (rat) acetate supp... |
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T0230 |
Prasugrel
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LY640315,CS-747,PCR 4099 |
P2Y Receptor
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Prasugrel (CS-747) is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANGINA and MYOCARDIAL INFARCTION, as well as in those... |
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T39115 |
ABR-238901
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TLR
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ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products) and TLR4 (toll-like receptor 4). ABR-238901 has potential a... |
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T22323 |
Enoxaparin sodium
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Thrombin
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Enoxaparin sodium is a low-molecular-weight heparin (LMWH) that has recently been approved by the US FDA for use in patients with medically managed ST-segment myocardial infarction (STEMI), or STEMI with subsequent percu... |
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T24873 |
TGX-115
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TGX 115 |
PI3K
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TGX-115 is a cell-permeable and potent inhibitor of the PI 3-K isoform p110β/p110δ (IC50 values of 0.13 μM for p110β and 0.63 μM for p110δ), an enzyme that regulates platelet adhesion and inhibits phosphoinositide (PI) 3... |
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T36569 |
KR-32568
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Sodium Channel
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KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM). KR-32568 exhibits potent cardioprotective effects. When used at a concentration of 10 μM, it restored cardiac systolic function in an isolated i... |
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T0815L |
Warfarin sodium
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An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, an... |
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T31206 |
Darexaban
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YM 150,Darexaban, Tanexaban,YM150 |
Factor Xa
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Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati... |
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T14390L |
(2R,3S)-Azelaprag
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Apelin receptor
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(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide is an Apelin receptor agonist with an EC50 for Apelin receptors of 0.012 µM.(2R,3S)-N-(4-(... |
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T37697L |
D-GsMTx4 TFA
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TRP/TRPV Channel
,
Piezo Channel
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D-GsMTx4 TFA, a selective spider venom peptide, is a TRPC1/6 and Piezo2 inhibitor that inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families, blocks cation-selective s... |
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T27581 |
Icrocaptide
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ITF 1697,ITF-1697,ITF1697 |
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Icrocaptide is used potentially for the treatment of acute myocardial infarction. |
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T28130 |
Naltiazem
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RO 236152,RO-236152,RO236152 |
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Naltiazem, a calcium channel antagonist, is used potentially for the treatment of arrhythmias, hypertension and myocardial infarction. |
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T24746 |
Zalunfiban
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RUC4,RUC 4,RUC-4 |
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RUC-4 is an aIIb 3 antagonist. It is also used for prehospital therapy of myocardial infarction. |
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T34327 |
Ridogrel
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R-70416,R 68070,R-68070,R70416,R 70416,R68070 |
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Lidogrell is a dual-acting agent that can be used to prevent systemic thromboembolism and as an adjunct to thrombolytic therapy in acute myocardial infarction. |
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T69078 |
Tiapamil Free Base
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Tiapamil Free Base is a phenylethylamine derivative that acts as a calcium antagonist showing hemodynamic effects in patients with acute myocardial infarction. |
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T61540 |
F15845
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F 15845 is a potent and persistent blocker of the sodium current. It possesses cardioprotective properties and exhibits both anti-ischemic activity and short- and long-term cardioprotection following myocardial infarctio... |
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T37697 |
D-GsMTx4
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D-GsMTx4 |
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TRPC1/6 and Piezo2 inhibitor. Exhibits same effect as L-enantiomer, GsMTx4 (Cat. No. 4912) on TRPC channels. Inhibits mechanosensitive currents by ~70%. Protects against myocardial infarction in mouse ischemia/reperfusi... |
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T22685 |
CP-471474
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CP 471474 |
Others
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Broad spectrum MMP inhibitor (IC<sub>50</sub> values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infa... |
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T11740L |
Delcasertib acetate
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KAI-9803,KID1-1,CS-9803,BMS-875944,Delcasertib acetate（949100-39-4 free base） |
PKC
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Delcasertib acetate is a selective δ protein kinase C (δPKC) inhibitor for the study of acute myocardial infarction and pain. |
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T62878 |
Zalunfiban dihydrochloride
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|
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Zalunfiban (RUC-4) dihydrochloride is a selective and potent platelet αIIbβ3 antagonist with an IC50 value of 45 nM. Zalunfiban dihydrochloride can be used to study myocardial infarction. |
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T71800 |
Metoprolol HCl
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Metoprolol is a selective β1 receptor blocker medication. It is used to treat high blood pressure, chest pain due to poor blood flow to the heart, and a number of conditions involving an abnormally fast heart rate. It is... |
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T73240 |
PDE5-IN-4
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PDE5-IN-4, a phosphodiesterase 5 (PDE5) inhibitor, is utilized in research concerning acute myocardial infarction and reperfusion-related damage, gastrointestinal diseases, diabetic complications, and liver failure. |
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T77026 |
Goflikicept
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|
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Goflikicept (RPH 104), a hybrid protein, selectively targets and neutralizes circulating IL-1ß and IL-1α. This compound shows promise for the investigation of ST-segment elevation myocardial infarction (STEMI) [1]. |
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T38800 |
MMPI-1154
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MMPI-1154 is a highly promising imidazole-carboxylic acid (ICA) MMP-2 inhibitor (IC 50 = 6.6 μM) with excellent cardio-cytoprotective properties. It is specifically designed for the study of acute myocardial infarction. ... |
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T73661 |
Delcasertib hydrochloride
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Delcasertib (KAI-9803) hydrochloride, a potent and selective δ-protein kinase C (δPKC) inhibitor, shows promise in reducing ischemia and reperfusion injury in animal models of acute myocardial infarction (MI) [1] [2]. |
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T77166 |
Rovelizumab
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Rovelizumab, a humanized monoclonal leukointegrin antibody, targets CD11/CD18 cell adhesion proteins. It has potential applications in the research of multiple sclerosis (MS), hemorrhagic shock, myocardial infarction (MI... |
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T77163 |
Pexelizumab
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Pexelizumab (h5G1.1-SC), a humanized scFv monoclonal antibody, targets the C5 complement component, thereby inhibiting apoptosis and leukocyte infiltration. It is utilized in researching cerebral ischemia-reperfusion (IR... |
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T62992 |
Trandolapril hydrochloride
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|
|
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Trandolapril (RU44570) hydrochloride is a non-mercapto precursor compound that is hydrolysed to active diacetyl (Trandolapril hydrochlorideat). Trandolapril hydrochloride has been studied in hypertension and congestive h... |
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T62507 |
Protease-Activated Receptor-1 antagonist 1
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Protease-Activated Receptor-1 antagonist 1 (Compound 13) is a protease-activated receptor 1 (PAR-1) antagonist with an IC50 of 3 nM obtained by the FLIPR technique. antagonist 1 can be used to study thrombotic cardiovasc... |
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T62909 |
SGC agonist 2
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SGC agonist 2 is a potent soluble guanylate cyclase (SGC) agonist. SGC agonist 2 has potential for cardiovascular disease (heart failure, angina, pulmonary hypertension, myocardial infarction) and fibrotic disease (renal... |
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T36223 |
MitoA
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MitoA is a ratiometric mass spectrometry probe that can be used for assessing changes in H2S within mitochondria in vivo. MitoA contains a triphenylphosphonium cation component that drives its accumulation in mitochondri... |
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T80130 |
SDF-1α (human)
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CXCR
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SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processes such as stem cell homing, retention, survival, and proliferat... |
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T83043 |
Anti-MI/R injury agent 1
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|
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Anti-MI/R injury agent 1 (compound 18), derived from Panaxatriol, represents an orally administered, potent agent against myocardial ischemia/reperfusion (MI/R) injury. It improves cell viability in cardiomyocytes subjec... |
